5-hydroxymethylfurfural can be used in medicine, synthetic resin plastics, aviation and diesel fuel additives. HMF molecules contain an aldehyde group and a hydroxyl group, which have good reactivity and can be easily converted into other useful compounds. The main derivatives of HMF are 2,5-furandialdehyde, 2,5-furandioic acid, levulinic acid, polymer monomers, etc. (1) fuel HMF and its disubstituted derivatives can replace petroleum fuel. Chhed et al. Used two-phase system to convert polysaccharides (inulin and sucrose) into HMF, then added various solid basic catalysts (almgox, Pd / MgO-ZrO2, LA / ZrO2, MgO / ZrO2, etc.) and some reagents, condensed and dehydrated to form a series of liquid alkanes. These products are * * substitutes for petroleum fuels. II) polymer monomer As a monomer, HMF can be used to synthesize polymer materials with optical activity and biodegradation, which can be used in fiber, rubber and casting industry. HMF can be oxidized to form 2,5-furandioic acid. 2,5- furan two formic acid is a stable furan derivative, which can be used for the preparation of drugs, pesticides, pesticides, fungicides and perfume. 2,5-furan dicarboxylic acid can also undergo halogenation, esterification, amidation and other reactions. One of the most important transformations is the formation of polyamide. Smay has synthesized a series of polyamides, which are characterized by high temperature resistance and can be widely used in the textile industry. The furan aromatic polyamide synthesized by Fang et al has regular structure and high molecular weight. The polymer solution has liquid crystal behavior and is soluble in concentrated sulfuric acid and NMP / LiCl. Kakinuma et al. Used fructose as raw material to prepare HMF under the catalysis of H2SO4, and then they used KMnO4 to carry out oxidation reaction to prepare 2,5-furandicarboxylic acid, with the conversion of 96.6%, and then reacted with propylene alcohol to generate 2,5-furanoacrylate. 2,5-furandioic acid can also be further converted into diacylchloride and diester derivatives. HMF can also be selectively reduced to 2,5-dihydroxymethylfuran, and then converted to 2,5-dichlorofuran. These reported furan monomers open the door of furan polymers. Furan resin HMF has many functional groups, which can be used to synthesize furan products with various properties (such as furan resin, furan compound aldehyde resin, furan asphalt mastic, etc.). Fang et al. Modified with furanyl ester as structural unit by means of copolymerization and grafting, and obtained photosensitive materials with excellent optical activity through transesterification. Elsa et al. Found that hmfae, which was obtained by the reaction of HMF with triethyl phosphate, could exchange with polymer ehh to form photosensitive polymer with excellent photo activity. Lasseughette et al. Studied the polycondensation of furodiformyl chloride and isosorbitol, and the polyester has the characteristics of biodegradation. Fine chemicals Drugs, levulinic acid and macrocyclic compounds with coordination ability can also be prepared by HMF. Dumesic et al. Reported that they prepared HMF in two-phase reaction system, and also prepared 2,5-dimethylfuran by this system. The hydroxyl groups on HMF can react with anhydrides or acids to form corresponding esters. Through selective oxidation of HMF, aldehyde group can be oxidized to carboxyl group while hydroxyl group can be oxidized to different compounds. These compounds are the leading compounds for the synthesis of drugs and the monomers for the synthesis of functional polymers. HMF itself is a compound with drug activity, which is contained in many traditional Chinese medicines. Starting from HMF, drugs with furan ring structure can be synthesized, such as ranitidine, a drug for ulcer treatment. In addition, HMF has insecticidal effect. In acid medium, the ring opening reaction of furan ring can produce levulinic acid. Levulinic acid can be produced by esterification, halogenation, hydrogenation, oxidative dehydrogenation, condensation and other chemical reactions. At the same time, the 4-position carbonyl is a potential chiral group, which can be obtained by asymmetric reduction. HMF can also be converted into 2,5-furandialdehyde to synthesize macrocyclic compounds, such as oxygen-containing cycloalkene. Nelson coordinated 2,5-furandialdehyde with metal ions such as Cu2 +, Cu + to form macrocyclic compounds. The product of condensation of 2,5-furandialdehyde with amines can coordinate with a series of metal ions. III. technological innovation Based on the research results of HMF at home and abroad, our team developed a new type of microbial and chemical catalyst, which can efficiently convert fructose into HMF. At the same time, according to the characteristics of the conversion process, the whole reaction system and extraction process were optimized to ensure the high yield of HMF.